生命科学学院

COLLEGE OF LIFE SCIENCE,CHINA WEST NORMAL UNIVERSITY
师资队伍team

侯万儒

2017-02-24 浏览量:892

侯万儒   

 

博士/教授
西华师范大学生命科学学院教授
生物化学与分子生物学、细胞生物学、遗传学专业硕士生导师

四川省有突出贡献的优秀专家
西华师范大学首席教授
四川省高校实验与技术系列高级职称评审专家
四川省新闻出版行业领军人才
四川省分子生物学精品课程负责人
西华师范大学生物化学与分子生物学科研创新团队负责人
中国细胞生物学学会会员
四川细胞生物学学会理事
四川中学生物教育研究会理事 

 

个人信息 


出生年月: 19549 
手机电话: 13990822808; 电子邮件:hwr@cwnu.edu.cn 
通讯地址: 四川 南充 顺庆区 师大路1号 西华师范大学生命科学学院 637009

 

教育背景


1978.03 - 1981.12 原四川师范学院生物系(现西华师范大学生命科学学院)生物科学 学士
2000.09 - 2003.07 四川农业大学 生物化学与分子生物学专业 博士
 

工作经历


2005.03至今      西华师范大学  首席教授
2001.12至今      西华师范大学  生命科学学院 教授
1995.12-2001.11  西华师范大学  生命科学学院 副教授
1994.01-1995.11  西华师范大学  生命科学学院 讲师 
  

主持及参研的科研课题 


1. 四川省科技厅科技支撑项目:人类核糖体蛋白L23a抗乳腺癌的药效与药理研究,(2014SZ0020),主持。

2. 南充市科技局重点项目:人类核糖体蛋白L23标签多肽(RPL23-SP) 抗癌的药效与药理研究,(14A0072),主持。

3. 四川省科技厅应用基础项目:真菌多糖对大熊猫MHC-I基因的影响效应探索及提高大熊猫免疫力的研究,(2011JY0135),主持。

4. 四川省科技厅应用基础项目:大熊猫核糖体蛋白各亚基基因的克隆与比较研究,(2009JY0061),主持。

5. 国家自然科学基金项目:松茸多糖TMP-A免疫调节活性及其相关分子机制的研究,(31200012),主研。

6. 四川省科技厅应用基础项目:珍稀食药用真菌松乳菇多糖免疫活性的分子机制及其资源开发关键技术,(2013JY0094),主研。

7. 四川省科技厅科技支撑项目:大型食药用真菌华美牛肝菌多糖BSF-1免疫调节活性机制的研究及其资源规模化生产的关键技术,(2014FZ0024),主研。

8. 四川省教育厅重大培育项目:松乳菇多糖(LDG-A)调控 NF-κB MAPKs信号转导通路的分子机制研究,(14CZ0016), 主研。

9. 校博士科研启动基金项目:乌头属药用植物铁棒锤中二萜生物碱与环氧合酶作用机制及构效关系研究,(11B019),主研。
 

 

研究领域 


1. 抗肿瘤小分子多肽药物筛选及分子机制研究。
2. 大熊猫,亚洲黑熊等珍稀野生动物基因组和蛋白组研究。
 

 

专利申请


1. 国家发明专利:人类核糖体蛋白L23标签多肽在制备抗癌药物中的应用,西华师范大学,专利授权号:ZL201210031964.3(第一申请人)

2. 国家发明专利:大肠杆菌BL21核糖体蛋白亚基L36在制备抗癌药物中的应用,西华师范大学,专利公开号:201110313917.3.3.(第一申请人) 


代表论文


1.Wanru Hou*, Yu Chen, Xia Wu, Jinchu Hu, Zhengsong Peng, Jun Yang, Zongxiang Tang, Caiquan Zhou, Yuming Li, Shikui Yang, Yujie Du, Linglu Kong, Zhenglong Ren, Huaiyu Zhang, Surong Shuai, A complete mitochondrial genome sequence of Asian black bear Sichuan subspecies (Ursus thibetanus mupinensis), International Journal of Biological Sciences, 2007, 3 (2): 85-90. (IF: 4.509)

2. Wanru Hou*, Yujie Du, Yu Chen, Xia Wu, Zhengsong Peng, Jun Yang, Caiquan Zhou, Nucleotide sequence of cDNA encoding the mitochondrial precursor protein of the ATPase inhibitor from the giant panda (Ailuropoda melanoleuca), DNA and Cell Biology, 2007, 26 (11): 799-802. (IF: 2.055)

3. Yujie Du, Xiaoyan Luo, Yanzhe Hao, Tian Zhang, Wanru Hou*, cDNA Cloning and Overexpression of Acidic Ribosomal Phosphoprotein P1 Gene (RPLP1) from the Giant Panda, International Journal of Biological Sciences, 2007, 3 (7): 428 - 433. (IF: 4.509)   

4. Wanru Hou*, Genlou Sun, Yu Chen, Xia Wu, Zhengsong Peng, Caiquan Zhou, Molecular cloning of ribosomal protein L26 (RPL26) cDNA from Ailuropoda melanoleuca and its potential value in phylogenetic study, Biochemical Systematics and Ecology, 2008, 36 (3), 194–200. (IF: 0.967)

5. Yanzhe Hao, Wanru Hou*, Yiling Hou, Yujie Du,Tian Zhang, Zhengsong Peng, cDNA, genomic sequence cloning and overexpression of ribosomal protein S25 gene (RPS25) from the Giant Panda, Molecular Biology Reports, 2009, 36 (8): 2139-2145. (IF: 2.024)

6. Yiling Hou, Wanru Hou*, Zhenglong Ren*, Yanzhe Hao, Tian Zhang, cDNA cloning and overexpression of ribosomal protein S19 gene (RPS19) from the Giant Panda, 2009, DNA and Cell Biology, 28 (1): 41-47. (IF: 2.055)  

7. Wanru Hou*, Yiling Hou, Yujie Du , Tian Zhang , Yanzhe Hao, cDNA, genomic sequence cloning and overexpression of glyceraldehyde-3-phosphate dehydrogenase gene (GAPDH) from the Giant Panda, Molecular Biology, 2010, 44 (2): 235–242. (IF: 0.718)

8. Wanru Hou*, Yun Tang, Yiling Hou, Yan Song, Tian Zhang, Guangfu Wu, cDNA, genomic sequence cloning, and overexpression of EIF1 from the giant panda (Ailuropoda Melanoleuca) and the black bear (Ursus Thibetanus Mupinensis), Nucleosides and Nucleotides, 2010, 29 (7): 547 - 561. (IF: 1.018)

9.  Guangfu WuYiling HouWanru Hou*Yan SongTian ZhangGiant panda ribosomal protein S14: cDNA, genomic sequence cloning, sequence analysis, and overexpressionGenetics and Molecular Research, 2010, 9(4): 2004-2015(IF: 0.775)

10. Wanru Hou*, Yiling Hou, Guangfu Wu, Yan Song, Xiulan Su, Bing Sun, Jun Li, cDNA, genomic sequence cloning and overexpression of ribosomal protein gene L9 (rpL9) of the giant panda (Ailuropoda melanoleuca), Genetics and Molecular Research, 2011, 10 (3): 1576-1588. (IF: 0.775)

11. Xiang Ding, Yiling Hou, Wanru Hou*, Structure feature and antitumor activity of a novel polysaccharide isolated from Lactarius deliciosus Gray, Carbohydrate Polymers, 2012, 89 (2): 397-402. (IF: 4.074)

12. Bing Sun, Yiling Hou, Wanru Hou*, Sinan Zhang, Xiang Ding, Xiulan Su, cDNA Cloning, Overexpression, Purification and Pharmacologic Evaluation for Anticancer Activity of Ribosomal Protein L23A Gene (RPL23A) from the Giant Panda, International Journal of Molecular Sciences, 2012, 13 (2): 2133-2147. (IF: 2.862)    

13. Yujie Du, Yiling Hou, Wanru Hou*, Cloning and overexpression of an important functional gene ATP6V1F encoding a component of vacuolar ATPase from the Giant Panda (Ailuropoda melanoleuca), Molecular Biology Reports, 2012, 39 (5): 5761-5766. (IF: 2.024)

14. Xiulan Su, Yiling Hou, Xianghui Yan, Xiang Ding, Wanru Hou*, Bing Sun, Sinan Zhang, Expression, purification, and evaluation for anticancer activity of ribosomal protein L31 gene (RPL31) from the giant panda (Ailuropoda melanoleuca), Molecular Biology Reports, 2012, 39 (9): 8945-8954 (IF: 2.024)

15. Wanru Hou*, Yiling Hou, Xiang Ding, Ting Wang, cDNA, genomic sequence cloning and overexpression of giant panda (Ailuropoda melanoleuca) mitochondrial ATP synthase ATP5G1, Genetics and Molecular Research, 2012, 11 (3): 3164-3174. (IF:0.775)                                                                          

16. Xiang Ding*, Yiling Hou, Wanru Hou, Structure elucidation and antioxidant activity of a novel polysaccharide isolated from Boletus speciosus Forst, International Journal of Biological Macromolecules, 2012, 50 (3): 613-618. (IF: 2.858)

17. Yujie Du, Yiling Hou, Wanru Hou*, Molecular characterization of a gene POLR2H encoded an essential subunit for RNA polymerase II from the Giant Panda (Ailuropoda Melanoleuca), Molecular Biology Reports, 2013, 40 (2): 1495-1498. (IF: 2.024)               

18. Fang Wang, Yiling Hou, Xiang Ding*, Wanru Hou, Bo Song, Ting Wang, Jian Li, Yichun Zeng, Structure elucidation and antioxidant effect of a polysaccharide from Lactarius camphoratum ( Bull. ) Fr., International Journal of Biological Macromolecules, 2013, 62 (11):  131-136. (IF: 2.858)

19. Yiling Hou, Xiang Ding, Wanru Hou*, Bo song, Ting Wang, Fang Wang, Jian Li, Jie Zhong, Ting Xu, Binxiang Ma, Hongqing Zhu, Junhua Li, Jincen Zhong, Overexpression, purification, and pharmacologic evaluation of anticancer activity of ribosomal protein L24 from the giant panda (Ailuropoda melanoleuca), Genetics and Molecular Research, 2013, 12 (2): 4735-4750. (IF: 0.775)

20. Yiling Hou, Xiang Ding*, Wanru Hou, Jie Zhong, Hongqing Zhu, Binxiang Ma, Ting Xu, Junhua Li, Anti-microorganism, anti-tumor, and immune activities of a novel polysaccharide isolated from Tricholoma matsutake, Pharmacognosy Magazine, 2013, 9 (35): 244-249. (IF:1.256)

21. Ting Wang, Yiling Hou, Xiang Ding*, Bo Song, Fang Wang, Wanru Hou, Overexpression, Purification, Molecular characterization and Pharmacologic evaluation for anticancer activity of Ribosomal protein S23 from the Giant Panda (Ailuropoda melanoleuca), Molecular Medicine Reports, 2013, 7 (6): 1875-1882. (IF: 1.554)  

22. Yiling Hou, Xiang Ding*, Wanru Hou, Bo Song, Ting Wang, Fang Wang, Jincen Zhong, Immunostimulant activity of a novel polysaccharide isolated from lactarius deliciosus (L. ex Fr.) Gray, Indian Journal of Pharmaceutical Sciences, 2013, 75 (4): 393-399 (IF: 0.479)

23. Yiling Hou, Xiang Ding*, Wanru Hou, Jincen Zhong, Bo Song, Ting Wang, Fang Wang, Morphological and genetic characterization and optimization of fermentation conditions of Xiaojin Tricholoma matsutake, Journal of Food Agriculture and Environment, 2013, 11 (1): 807-812. (IF: 0.435)

24. Yujie Du, Yiling Hou, Wanru Hou*, Nucleotide Sequences of an Important Functional Gene hnRNPA2/B1 from Ailuropoda melanoleuca and Ursus thibetanus mupinensis and its Potential Value in Phylogenetic Study, Nucleosides, Nucleotides and Nucleic Acids, 2014, 33 (1): 18-30. (IF: 1.018)

25. Yiling Hou, Xiang Ding*, Wanru Hou, Bo Song, Ting Wang, Fang Wang, Jie Zhong,Ting Xu, Jincen Zhong, Pharmacological evaluation for anticancer and immune activities of a novel polysaccharide isolated from Boletus speciosus Frost., Molecular Medicine Reports, 2014, 9 (4): 1337-1344. (IF: 1.554)

26. Jian Li#, Yiling Hou#, Xiang Ding*, Wanru Hou, Bo Song, Yichun Zeng, Overexpression, purification, molecular characterization and the effect on tumor growth of Ribosomal protein L22 from the Giant Panda (Ailuropoda melanoleuca), Molecular Biology Reports, 2014, 41 (5): 3529-3539. (IF: 2.024)                                                                                                                                                                          

27. Bo Song, Yiling Hou, Xiang Ding, Ting Wang, Fang Wang, Jincen Zhong, Ting Xu, Jie Zhong, Wanru Hou*, Surong Shuai*, Comparative analysis and molecular characterization of the genomic sequences and proteins of FABP4 and FABP5 which bind long-chain fatty acids and other hydrophobic ligandsfrom the Giant Panda (Ailuropoda Melanoleuca), Genetics and Molecular Research, 2014, 13 (1): 992-1004. (IF: 0.775)

28. Yichun Zeng#, Yiling Hou#, Xiang Ding*, Wanru Hou, Jian Li, Comparative analysis and molecular characterization of a gene BANF1 encoded a DNA-binding protein during mitosis from the Giant Panda and Black Bear, Nucleosides, Nucleotides and Nucleic Acids, 2014, 33 (8): 536-551. (IF: 1.018)

30. Xiang Ding, Yiling Hou*, Wanru Hou, Yuanxiu Zhu, Lei Fu, Hongqing Zhu, Structure elucidation and anti-tumor activities of water-soluble oligosaccharides from Lactarius deliciosus (L. ex Fr.) Gray, Pharmacognosy Magazine, 2015, 11 (44): 716-723. (IF: 1.256).

31. Xiang Ding, Yiling Hou*, Yuanxiu Zhu, Panpan Wang, Lei Fu, Hongqing Zhu, Nan Zhang, Hang Qin, Wei Qu, Fang Wang, Wanru Hou, Structure elucidation, anticancer and antioxidant activities of a novel polysaccharide from Gomphus clavatus Gray, Oncology Reports, 2015, 33(6), 3162-3170. (IF: 2.301)

 

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